Ontology highlight
ABSTRACT:
SUBMITTER: Morin RD
PROVIDER: S-EPMC3210554 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Nature 20110727 7360
Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched normal DNA from 13 DLBCL cases and one FL case to identify genes with mutations in B-cell NHL. We analysed RNA-seq data from these and another 113 NHLs to identify genes with candidate mutations, and then re-sequenced tumour and matched normal DNA from these cases to confirm 109 genes with multiple somatic mutations. Genes with roles in his ...[more]