ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase.
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ABSTRACT:
SUBMITTER: Sun T
PROVIDER: S-EPMC3212355 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase.
Sun Tianjun T Hayakawa Koto K Fraser Marie E ME
Acta crystallographica. Section F, Structural biology and crystallization communications 20110924 Pt 10
Human ATP-citrate lyase (EC 2.3.3.8) is the cytoplasmic enzyme that catalyzes the production of acetyl-CoA from citrate, CoA and ATP. The amino-terminal portion of the enzyme, containing residues 1-817, was crystallized in the presence of tartrate, ATP and magnesium ions. The crystals diffracted to 2.3 Å resolution. The structure shows ADP-Mg(2+) bound to the domain that possesses the ATP-grasp fold. The structure demonstrates that this crystal form could be used to investigate the structures of ...[more]
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