Ontology highlight
ABSTRACT:
SUBMITTER: Even A
PROVIDER: S-EPMC8497606 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Even Aviel A Morelli Giovanni G Turchetto Silvia S Shilian Michal M Bail Romain Le RL Laguesse Sophie S Krusy Nathalie N Brisker Ariel A Brandis Alexander A Inbar Shani S Chariot Alain A Saudou Frédéric F Dietrich Paula P Dragatsis Ioannis I Brone Bert B Broix Loïc L Rigo Jean-Michel JM Weil Miguel M Nguyen Laurent L
Nature communications 20211007 1
Microtubule (MT)-based transport is an evolutionary conserved process finely tuned by posttranslational modifications. Among them, α-tubulin acetylation, primarily catalyzed by a vesicular pool of α-tubulin N-acetyltransferase 1 (Atat1), promotes the recruitment and processivity of molecular motors along MT tracks. However, the mechanism that controls Atat1 activity remains poorly understood. Here, we show that ATP-citrate lyase (Acly) is enriched in vesicles and provide Acetyl-Coenzyme-A (Acety ...[more]