Targeting SRC in glioblastoma tumors and brain metastases: rationale and preclinical studies.
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ABSTRACT:
SUBMITTER: Ahluwalia MS
PROVIDER: S-EPMC3212431 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Targeting SRC in glioblastoma tumors and brain metastases: rationale and preclinical studies.
Ahluwalia Manmeet S MS de Groot John J Liu Wei Michael WM Gladson Candece L CL
Cancer letters 20101201 2
Glioblastoma (GBM) is an extremely aggressive, infiltrative tumor with a poor prognosis. The regulatory approval of bevacizumab for recurrent GBM has confirmed that molecularly targeted agents have potential for GBM treatment. Preclinical data showing that SRC and SRC-family kinases (SFKs) mediate intracellular signaling pathways controlling key biologic/oncogenic processes provide a strong rationale for investigating SRC/SFK inhibitors, e.g., dasatinib, in GBM and clinical studies are underway. ...[more]
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