Ontology highlight
ABSTRACT:
SUBMITTER: Benet M
PROVIDER: S-EPMC3212639 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Benet Marta M Dulman Robin Yates RY Suzme Raffi R de Miera Eleazar Vega-Saenz EV Vega Martha E ME Nguyen Thuy T Zavadil Jiri J Pellicer Angel A
Journal of cellular physiology 20120601 6
Previously, we have shown that wild type N-ras (wt N-ras) harbors an anti-malignant effect against mutated Ras and in tumors without Ras mutations. To investigate the molecular bases of this anti-malignant activity, we have studied the potency of this anti-malignant effect in a model system against SV40 large T antigen (SV40T). We show that wild-type N-ras (wt N-ras) counteracts the effects of SV40T in NIH3T3 cells as seen by a decrease in proliferation, anchorage independence and changes in mig ...[more]