Ontology highlight
ABSTRACT:
SUBMITTER: Ippolito GC
PROVIDER: S-EPMC3212734 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Ippolito Gregory C GC Schelonka Robert L RL Zemlin Michael M Ivanov Ivaylo I II Kobayashi Ryoki R Zemlin Cosima C Gartland G Larry GL Nitschke Lars L Pelkonen Jukka J Fujihashi Kohtaro K Rajewsky Klaus K Schroeder Harry W HW
The Journal of experimental medicine 20060605 6
Tyrosine and glycine constitute 40% of complementarity determining region 3 of the immunoglobulin heavy chain (CDR-H3), the center of the classic antigen-binding site. To assess the role of D(H) RF1-encoded tyrosine and glycine in regulating CDR-H3 content and potentially influencing B cell function, we created mice limited to a single D(H) encoding asparagine, histidine, and arginines in RF1. Tyrosine and glycine content in CDR-H3 was halved. Bone marrow and spleen mature B cell and peritoneal ...[more]