Ontology highlight
ABSTRACT:
SUBMITTER: Zeippen C
PROVIDER: S-EPMC5469271 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Zeippen Caroline C Javaux Justine J Xiao Xue X Ledecq Marina M Mast Jan J Farnir Frédéric F Vanderplasschen Alain A Stevenson Philip P Gillet Laurent L
Journal of virology 20170609 13
Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a gammaherpesvirus of mice, is transmitted sexually. We show that this depends on the major virion envelope glycoprotein gp150. gp150 is redundant for host entry, and <i>in vitro</i>, it regulates rather than promotes cell binding. We show that gp150-deficient MuHV-4 reaches and replicates normally in the fema ...[more]