De novo origin of human protein-coding genes.
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ABSTRACT:
SUBMITTER: Wu DD
PROVIDER: S-EPMC3213175 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
De novo origin of human protein-coding genes.
Wu Dong-Dong DD Irwin David M DM Zhang Ya-Ping YP
PLoS genetics 20111110 11
The de novo origin of a new protein-coding gene from non-coding DNA is considered to be a very rare occurrence in genomes. Here we identify 60 new protein-coding genes that originated de novo on the human lineage since divergence from the chimpanzee. The functionality of these genes is supported by both transcriptional and proteomic evidence. RNA-seq data indicate that these genes have their highest expression levels in the cerebral cortex and testes, which might suggest that these genes contrib ...[more]
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