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4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one.

ABSTRACT: 4-Phenyl-1H-1,5-benzodiazepin-2(3H)-one reacts in the pres-ence of a concentrated aqueous solution of sodium hydroxide and a quaternary ammonium salt (as catalyst) in benzene (phase transfer catalysis) with propargyl bromide, affording the title benzodiazepine derivative, C(18)H(14)N(2)O. In the mol-ecule, the mean plane of the propargyl substituent is almost perpendicular with that of the amide group [dihedral angle = 87.81?(8)°]. In the crystal, the molecules are linked by C-H?O and C-H?N inter-actions.

SUBMITTER: Loughzail M 

PROVIDER: S-EPMC3213519 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one.

Loughzail Mohamed M   Fernandes José A JA   Baouid Abdesselam A   Essaber Mohamed M   Cavaleiro José A S JA   Almeida Paz Filipe A FA  

Acta crystallographica. Section E, Structure reports online 20110723 Pt 8

4-Phenyl-1H-1,5-benzodiazepin-2(3H)-one reacts in the pres-ence of a concentrated aqueous solution of sodium hydroxide and a quaternary ammonium salt (as catalyst) in benzene (phase transfer catalysis) with propargyl bromide, affording the title benzodiazepine derivative, C(18)H(14)N(2)O. In the mol-ecule, the mean plane of the propargyl substituent is almost perpendicular with that of the amide group [dihedral angle = 87.81 (8)°]. In the crystal, the molecules are linked by C-H⋯O and C-H⋯N inte  ...[more]

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