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(R)-(+)-2-{[(3-Methyl-4-nitro-pyridin-2-yl)meth-yl]sulfin-yl}-1H-benzimidazole.

ABSTRACT: The title compound, C(14)H(12)N(4)O(3)S, is an inter-mediate of Dexlansoprazole, a proton pump inhibitor (PPI) mainly developed for anti-ulcer activity. The absolute configuration of the title compound was determined as R. The crystal structure reveals that the mol-ecules form chains along the b axis through N-H?N and C-H?O hydrogen-bonded dimers. These chains are connected via weak C-H?O hydrogen bonds.

SUBMITTER: Naga Raju M

PROVIDER: S-EPMC3213621 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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(R)-(+)-2-{[(3-Methyl-4-nitro-pyridin-2-yl)meth-yl]sulfin-yl}-1H-benzimidazole.

Naga Raju Manne M Uday Kumar Neelam N Kolla Naveenkumar N Bandichhor Rakeshwar R Vishweshwar Peddy P

Acta crystallographica. Section E, Structure reports online 20110730 Pt 8

The title compound, C(14)H(12)N(4)O(3)S, is an inter-mediate of Dexlansoprazole, a proton pump inhibitor (PPI) mainly developed for anti-ulcer activity. The absolute configuration of the title compound was determined as R. The crystal structure reveals that the mol-ecules form chains along the b axis through N-H⋯N and C-H⋯O hydrogen-bonded dimers. These chains are connected via weak C-H⋯O hydrogen bonds. ...[more]

PMID: 22091198

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