Ontology highlight
ABSTRACT:
SUBMITTER: Varfolomeev E
PROVIDER: S-EPMC321448 | biostudies-literature | 2004 Feb
REPOSITORIES: biostudies-literature
Varfolomeev Eugene E Kischkel Frank F Martin Flavius F Seshasayee Dhaya D Wang Hua H Lawrence David D Olsson Christine C Tom Lucrece L Erickson Sharon S French Dorothy D Schow Peter P Grewal Iqbal S IS Ashkenazi Avi A
Molecular and cellular biology 20040201 3
APRIL (a proliferation-inducing ligand) is a member of the tumor necrosis factor (TNF) superfamily. APRIL mRNA shows high levels of expression in tumors of different origin and a low level of expression in normal cells. APRIL shares two TNF receptor family members, TACI and BCMA, with another TNF homolog, BLyS/BAFF. BLyS is involved in regulation of B-cell activation and survival and also binds to a third receptor, BR3/BAFF-R, which is not shared with APRIL. Recombinant APRIL and BLyS induce acc ...[more]