Normal B cell development and Pax5 expression in Thy28/ThyN1-deficient mice.
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ABSTRACT:
SUBMITTER: Kitaura F
PROVIDER: S-EPMC6645560 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Normal B cell development and Pax5 expression in Thy28/ThyN1-deficient mice.
Kitaura Fusako F Yuno Miyuki M Fujita Toshitsugu T Wakana Shigeharu S Ueda Jun J Yamagata Kazuo K Fujii Hodaka H
PloS one 20190722 7
Thy28, also known as ThyN1, is a highly conserved nuclear protein. We previously showed that in a chicken mature B cell line, Thy28 binds to the promoter of the gene encoding Pax5, a transcription factor essential for B cell development, and positively regulates its expression. Here, we generated a Thy28-deficient mouse line to analyze its potential role in B cell development in mice. Thy28-deficient mice showed normal development of B cells, and the expression of Pax5 was comparable between wil ...[more]
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