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Microcantilevers modified by specific peptide for selective detection of trimethylamine.


ABSTRACT: We report a biosensor based on a microcantilever that is modified by a specific peptide for highly selective detection of trimethylamine (TMA). The assay is based on binding-induced bending of the peptide functionalized microcantilevers. The sensor is selectively responsive to TMA. The amplitude of microcantilever bending at equilibrium is a function of the concentration of TMA with a dynamic range from 8 ppm to 800 ppm. The detection limit is approximately 8 ppm. There is a good intra-sensor and an acceptable inter-sensor reproducibility as evidenced by the standard deviation of 5% and 15%, respectively.

SUBMITTER: Huang X 

PROVIDER: S-EPMC3214668 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Microcantilevers modified by specific peptide for selective detection of trimethylamine.

Huang Xin X   Li Mingfu M   Xu Xiaohe X   Chen Hongjun H   Ji Hai-Feng HF   Zhu Shuifang S  

Biosensors & bioelectronics 20110916 1


We report a biosensor based on a microcantilever that is modified by a specific peptide for highly selective detection of trimethylamine (TMA). The assay is based on binding-induced bending of the peptide functionalized microcantilevers. The sensor is selectively responsive to TMA. The amplitude of microcantilever bending at equilibrium is a function of the concentration of TMA with a dynamic range from 8 ppm to 800 ppm. The detection limit is approximately 8 ppm. There is a good intra-sensor an  ...[more]

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