Dataset Information

Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites.

ABSTRACT:

Introduction

The current radiofrequency ablation technique requires invasive needle placement. On the other hand, most of the common photothermal therapeutic methods are limited by lack of accuracy of targeting. Gold and magnetic nanoparticles offer the potential to heat tumor tissue selectively at the cellular level by noninvasive interaction with laser and radiofrequency.

Methods

Gold nanospheres and gold-coated magnetic nanocomposites were used for inducing hyperthermia to treat subcutaneous Ehrlich carcinoma implanted in female mice.

Results

In mice treated with gold nanospheres, tumors continued to grow but at a slow rate. In contrast, more than 50% of the tumors treated with gold-coated magnetic nanocomposites completely disappeared.

Conclusion

This simple and noninvasive method shows great promise as a technique for selective magnetic photothermal treatment.

SUBMITTER: Elsherbini AA

PROVIDER: S-EPMC3215156 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Publications

Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites.

Elsherbini Alsayed A M AA Saber Mahmoud M Aggag Mohamed M El-Shahawy Ahmed A Shokier Hesham A A HA

International journal of nanomedicine 20110928

<h4>Introduction</h4>The current radiofrequency ablation technique requires invasive needle placement. On the other hand, most of the common photothermal therapeutic methods are limited by lack of accuracy of targeting. Gold and magnetic nanoparticles offer the potential to heat tumor tissue selectively at the cellular level by noninvasive interaction with laser and radiofrequency.<h4>Methods</h4>Gold nanospheres and gold-coated magnetic nanocomposites were used for inducing hyperthermia to trea ...[more]

PMID: 22114479

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Project description:Melanoma is the most aggressive and metastasis-prone form of skin cancer. Conventional therapies include chemotherapeutic agents, either as small molecules or carried by FDA-approved nanostructures. However, systemic toxicity and side effects still remain as major drawbacks. With the advancement of nanomedicine, new delivery strategies emerge at a regular pace, aiming to overcome these challenges. Stimulus-responsive drug delivery systems might considerably reduce systemic toxicity and side-effects by limiting drug release to the affected area. Herein, we report the development of paclitaxel-loaded lipid-coated manganese ferrite magnetic nanoparticles (PTX-LMNP) as magnetosomes synthetic analogs, envisaging the combined chemo-magnetic hyperthermia treatment of melanoma. PTX-LMNP physicochemical properties were verified, including their shape, size, crystallinity, FTIR spectrum, magnetization profile, and temperature profile under magnetic hyperthermia (MHT). Their diffusion in porcine ear skin (a model for human skin) was investigated after intradermal administration via fluorescence microscopy. Cumulative PTX release kinetics under different temperatures, either preceded or not by MHT, were assessed. Intrinsic cytotoxicity against B16F10 cells was determined via neutral red uptake assay after 48 h of incubation (long-term assay), as well as B16F10 cells viability after 1 h of incubation (short-term assay), followed by MHT. PTX-LMNP-mediated MHT triggers PTX release, allowing its thermal-modulated local delivery to diseased sites, within short timeframes. Moreover, half-maximal PTX inhibitory concentration (IC50) could be significantly reduced relatively to free PTX (142,500×) and Taxol® (340×). Therefore, the dual chemo-MHT therapy mediated by intratumorally injected PTX-LMNP stands out as a promising alternative to efficiently deliver PTX to melanoma cells, consequently reducing systemic side effects commonly associated with conventional chemotherapies.

Dataset Information

Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites.

Introduction

Methods

Results

Conclusion

Publications

Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites.

Similar Datasets

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