Mitochondrial SIRT3: a new potential therapeutic target for metabolic syndrome.
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ABSTRACT:
SUBMITTER: Yoshino J
PROVIDER: S-EPMC3215590 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Mitochondrial SIRT3: a new potential therapeutic target for metabolic syndrome.
Yoshino Jun J Imai Shin-ichiro S
Molecular cell 20111001 2
In this issue of Molecular Cell, Hirschey et al. demonstrate that loss of the NAD(+)-dependent deacetylase SIRT3 and resultant mitochondrial protein hyperacetylation play a critical role in the pathogenesis of metabolic syndrome, providing new insights into the therapeutic potential of SIRT3. ...[more]
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