Ontology highlight
ABSTRACT:
SUBMITTER: Knight JS
PROVIDER: S-EPMC5621930 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Knight Jason S JS Meng He H Coit Patrick P Yalavarthi Srilakshmi S Sule Gautam G Gandhi Alex A AA Grenn Robert C RC Mazza Levi F LF Ali Ramadan A RA Renauer Paul P Wren Jonathan D JD Bockenstedt Paula L PL Wang Hui H Eitzman Daniel T DT Sawalha Amr H AH
JCI insight 20170921 18
Antiphospholipid antibodies, present in one-third of lupus patients, increase the risk of thrombosis. We recently reported a key role for neutrophils - neutrophil extracellular traps (NETs), in particular - in the thrombotic events that define antiphospholipid syndrome (APS). To further elucidate the role of neutrophils in APS, we performed a comprehensive transcriptome analysis of neutrophils isolated from patients with primary APS. Moreover, APS-associated venous thrombosis was modeled by trea ...[more]