Ontology highlight
ABSTRACT:
SUBMITTER: Siegert S
PROVIDER: S-EPMC3215737 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Siegert Stefanie S Huang Hsin-Ying HY Yang Chen-Ying CY Scarpellino Leonardo L Carrie Lucie L Essex Sarah S Nelson Peter J PJ Heikenwalder Matthias M Acha-Orbea Hans H Buckley Christopher D CD Marsland Benjamin J BJ Zehn Dietmar D Luther Sanjiv A SA
PloS one 20111114 11
Adaptive immune responses are initiated when T cells encounter antigen on dendritic cells (DC) in T zones of secondary lymphoid organs. T zones contain a 3-dimensional scaffold of fibroblastic reticular cells (FRC) but currently it is unclear how FRC influence T cell activation. Here we report that FRC lines and ex vivo FRC inhibit T cell proliferation but not differentiation. FRC share this feature with fibroblasts from non-lymphoid tissues as well as mesenchymal stromal cells. We identified FR ...[more]