Ontology highlight
ABSTRACT:
SUBMITTER: Baier CJ
PROVIDER: S-EPMC3216556 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Scientific reports 20110819
Cholesterol influences ion-channel function, distribution and clustering in the membrane, endocytosis, and exocytic sorting of the nicotinic acetylcholine receptor (AChR). We report the occurrence of a cholesterol recognition motif, here coined "CARC", in the transmembrane regions of AChR subunits that bear extensive contact with the surrounding lipid, and are thus optimally suited to convey cholesterol-mediated signaling from the latter. Three cholesterol molecules could be docked on the transm ...[more]