Ontology highlight
ABSTRACT:
SUBMITTER: Ma B
PROVIDER: S-EPMC3216621 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Scientific reports 20111103
Transport of mRNAs to diverse neuronal locations via RNA granules serves an important function in regulating protein synthesis within restricted sub-cellular domains. We recently detected the Huntington's disease protein huntingtin (Htt) in dendritic RNA granules; however, the functional significance of this localization is not known. Here we report that Htt and the huntingtin-associated protein 1 (HAP1) are co-localized with the microtubule motor proteins, the KIF5A kinesin and dynein, during d ...[more]