Ontology highlight
ABSTRACT:
SUBMITTER: Colin E
PROVIDER: S-EPMC2516882 | biostudies-other | 2008 Aug
REPOSITORIES: biostudies-other
Colin Emilie E Zala Diana D Liot Géraldine G Rangone Hélène H Borrell-Pagès Maria M Li Xiao-Jiang XJ Saudou Frédéric F Humbert Sandrine S
The EMBO journal 20080710 15
The transport of vesicles in neurons is a highly regulated process, with vesicles moving either anterogradely or retrogradely depending on the nature of the molecular motors, kinesins and dynein, respectively, which propel vesicles along microtubules (MTs). However, the mechanisms that determine the directionality of transport remain unclear. Huntingtin, the protein mutated in Huntington's disease, is a positive regulatory factor for vesicular transport. Huntingtin is phosphorylated at serine 42 ...[more]