Ontology highlight
ABSTRACT:
SUBMITTER: Kim KH
PROVIDER: S-EPMC3216666 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Kim Kyung Hee KH Toomre Derek D Bender Jeffrey R JR
Molecular biology of the cell 20110921 22
In addition to enhancing or repressing transcription, steroid hormone receptors rapidly transduce kinase activation signals. On ligand engagement, an N-terminus-truncated splice isoform of estrogen receptor (ER) α, ER46, triggers membrane-initiated signals, resulting in endothelial nitric oxide synthase (eNOS) activation and endothelial NO production. The orientation of ER46 at the plasma membrane is incompletely defined. With the use of ecliptic pHluorin-fused ER46, total internal reflection fl ...[more]