Ontology highlight
ABSTRACT:
SUBMITTER: Doucette CD
PROVIDER: S-EPMC3218208 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Doucette Christopher D CD Schwab David J DJ Wingreen Ned S NS Rabinowitz Joshua D JD
Nature chemical biology 20111016 12
Microbes survive in a variety of nutrient environments by modulating their intracellular metabolism. Balanced growth requires coordinated uptake of carbon and nitrogen, the primary substrates for biomass production. Yet the mechanisms that balance carbon and nitrogen uptake are poorly understood. We find in Escherichia coli that a sudden increase in nitrogen availability results in an almost immediate increase in glucose uptake. The concentrations of glycolytic intermediates and known regulators ...[more]