Ontology highlight
ABSTRACT:
SUBMITTER: Cline LL
PROVIDER: S-EPMC3218225 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Cline Lauren L LL Janout Vaclav V Fisher Michael M Juliano Rudolph L RL Regen Steven L SL
Bioconjugate chemistry 20111013 11
A series of diwalled and tetrawalled molecular umbrellas have been synthesized using cholic acid, spermidine, and lysine as starting materials. Coupling of these molecular umbrellas to an octaarginine peptide afforded agents that were capable of promoting the transport of small interfering RNA to HeLa cells, as judged by the knockdown of enhanced green fluorescent protein expression. The efficiency of this knockdown was found to increase with an increasing number of facially amphiphilic walls pr ...[more]