Ontology highlight
ABSTRACT:
SUBMITTER: Miller KH
PROVIDER: S-EPMC3218367 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Miller Katherine H KH Marqusee Susan S
Protein science : a publication of the Protein Society 20110912 10
Domain swapping is a type of oligomerization in which monomeric proteins exchange a structural element, resulting in oligomers whose subunits recapitulate the native, monomeric fold. It has been implicated as a potential mechanism for protein aggregation, which provides a strong impetus to understand the structural determinants and folding mechanisms that trigger domain swapping. Bovine pancreatic ribonuclease A (RNase A) is a well-studied protein known to domain swap under extreme conditions, s ...[more]