Ontology highlight
ABSTRACT:
SUBMITTER: Sejersted Y
PROVIDER: S-EPMC3219145 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Sejersted Yngve Y Hildrestrand Gunn A GA Kunke David D Rolseth Veslemøy V Krokeide Silje Z SZ Neurauter Christine G CG Suganthan Rajikala R Atneosen-Åsegg Monica M Fleming Aaron M AM Saugstad Ola D OD Burrows Cynthia J CJ Luna Luisa L Bjørås Magnar M
Proceedings of the National Academy of Sciences of the United States of America 20111107 46
Neural stem/progenitor cell proliferation and differentiation are required to replace damaged neurons and regain brain function after hypoxic-ischemic events. DNA base lesions accumulating during hypoxic-ischemic stress are removed by DNA glycosylases in the base-excision repair pathway to prevent cytotoxicity and mutagenesis. Expression of the DNA glycosylase endonuclease VIII-like 3 (Neil3) is confined to regenerative subregions in the embryonic and perinatal brains. Here we show profound neur ...[more]