Ontology highlight
ABSTRACT:
SUBMITTER: Xiao Z
PROVIDER: S-EPMC3219213 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Xiao Zhousheng Z Dallas Mark M Qiu Ni N Nicolella Daniel D Cao Li L Johnson Mark M Bonewald Lynda L Quarles L Darryl LD
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110331 7
We investigated whether polycystin-1 is a bone mechanosensor. We conditionally deleted Pkd1 in mature osteoblasts/osteocytes by crossing Dmp1-Cre with Pkd1(flox/m1Bei) mice, in which the m1Bei allele is nonfunctional. We assessed in wild-type and Pkd1-deficient mice the response to mechanical loading in vivo by ulna loading and ex vivo by measuring the response of isolated osteoblasts to fluid shear stress. We found that conditional Pkd1 heterozygotes (Dmp1-Cre;Pkd1(flox/+)) and null mice (Pkd1( ...[more]