Ontology highlight
ABSTRACT:
SUBMITTER: Pascal LE
PROVIDER: S-EPMC6593215 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Pascal Laura E LE Su Fei F Wang Dan D Ai Junkui J Song Qiong Q Wang Yujuan Y O'Malley Katherine J KJ Cross Brian B Rigatti Lora H LH Green Anthony A Dhir Rajiv R Wang Zhou Z
Neoplasia (New York, N.Y.) 20190621 8
ELL-associated factor 1 is a transcription elongation factor that shares significant homology and functional similarity to the androgen-responsive prostate tumor suppressor ELL-associated factor 2. EAF2 is frequently down-regulated in advanced prostate cancer and Eaf2 deletion in the mouse induced the development of murine prostatic intraepithelial neoplasia. Here we show that similar to EAF2, EAF1 is frequently down-regulated in advanced prostate cancer. Co-downregulation of EAF1 and EAF2 occur ...[more]