Ontology highlight
ABSTRACT:
SUBMITTER: Hatzirodos N
PROVIDER: S-EPMC3219214 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Hatzirodos Nicholas N Bayne Rosemary A RA Irving-Rodgers Helen F HF Hummitzsch Katja K Sabatier Laetitia L Lee Sam S Bonner Wendy W Gibson Mark A MA Rainey William E WE Carr Bruce R BR Mason Helen D HD Reinhardt Dieter P DP Anderson Richard A RA Rodgers Raymond J RJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110316 7
Although not often discussed, the ovaries of women with polycystic ovary syndrome (PCOS) show all the hallmarks of increased TGF-β activity, with increased amounts of fibrous tissue and collagen in the ovarian capsule or tunica albuginea and ovarian stroma. Recent studies suggest that PCOS could have fetal origins. Genetic studies of PCOS have also found linkage with a microsatellite located in intron 55 of the extracellular matrix protein fibrillin 3. Fibrillins regulate TGF-β bioactivity in ti ...[more]