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The role of TGF-? in polycystic ovary syndrome.

ABSTRACT: Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by chronic oligoanovulation and hyperandrogenism and associated with insulin resistance, type 2 diabetes, and cardiovascular risk. In recent years, genetic studies have linked PCOS to a dinucleotide marker D19S884 in the fibrillin 3 gene. Fibrillins make up the major component of microfibrils in the extracellular matrix (ECM) and interact with molecules in the ECM to regulate transforming growth factor ? (TGF-?) signaling. Therefore, variations in fibrillin 3 and subsequent dysregulation of TGF-? may contribute to the pathogenesis of PCOS. Here, we review the evidence from genetic studies supporting the role of TGF-? in PCOS and describe how TGF-? dysregulation may contribute to (1) the fetal origins of PCOS, (2) reproductive abnormalities in PCOS, and (3) cardiovascular and metabolic abnormalities in PCOS.

SUBMITTER: Raja-Khan N

PROVIDER: S-EPMC5933191 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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The role of TGF-β in polycystic ovary syndrome.

Raja-Khan Nazia N Urbanek Margrit M Rodgers Raymond J RJ Legro Richard S RS

Reproductive sciences (Thousand Oaks, Calif.) 20130412 1

Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by chronic oligoanovulation and hyperandrogenism and associated with insulin resistance, type 2 diabetes, and cardiovascular risk. In recent years, genetic studies have linked PCOS to a dinucleotide marker D19S884 in the fibrillin 3 gene. Fibrillins make up the major component of microfibrils in the extracellular matrix (ECM) and interact with molecules in the ECM to regulate transforming growth factor β (TGF-β) signal ...[more]

PMID: 23585338

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