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ABSTRACT: Introduction
Fluid responsiveness prediction is of utmost interest during acute respiratory distress syndrome (ARDS), but the performance of respiratory pulse pressure variation (?RESPPP) has scarcely been reported. In patients with ARDS, the pathophysiology of ?RESPPP may differ from that of healthy lungs because of low tidal volume (Vt), high respiratory rate, decreased lung and sometimes chest wall compliance, which increase alveolar and/or pleural pressure. We aimed to assess ?RESPPP in a large ARDS population.Methods
Our study population of nonarrhythmic ARDS patients without inspiratory effort were considered responders if their cardiac output increased by >10% after 500-ml volume expansion.Results
Among the 65 included patients (26 responders), the area under the receiver-operating curve (AUC) for ?RESPPP was 0.75 (95% confidence interval (CI95): 0.62 to 0.85), and a best cutoff of 5% yielded positive and negative likelihood ratios of 4.8 (CI95: 3.6 to 6.2) and 0.32 (CI95: 0.1 to 0.8), respectively. Adjusting ?RESPPP for Vt, airway driving pressure or respiratory variations in pulmonary artery occlusion pressure (?PAOP), a surrogate for pleural pressure variations, in 33 Swan-Ganz catheter carriers did not markedly improve its predictive performance. In patients with ?PAOP above its median value (4 mmHg), AUC for ?RESPPP was 1 (CI95: 0.73 to 1) as compared with 0.79 (CI95: 0.52 to 0.94) otherwise (P = 0.07). A 300-ml volume expansion induced a ? 2 mmHg increase of central venous pressure, suggesting a change in cardiac preload, in 40 patients, but none of the 28 of 40 nonresponders responded to an additional 200-ml volume expansion.Conclusions
During protective mechanical ventilation for early ARDS, partly because of insufficient changes in pleural pressure, ?RESPPP performance was poor. Careful fluid challenges may be a safe alternative.
SUBMITTER: Lakhal K
PROVIDER: S-EPMC3219343 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Critical care (London, England) 20110307 2
<h4>Introduction</h4>Fluid responsiveness prediction is of utmost interest during acute respiratory distress syndrome (ARDS), but the performance of respiratory pulse pressure variation (ΔRESPPP) has scarcely been reported. In patients with ARDS, the pathophysiology of ΔRESPPP may differ from that of healthy lungs because of low tidal volume (Vt), high respiratory rate, decreased lung and sometimes chest wall compliance, which increase alveolar and/or pleural pressure. We aimed to assess ΔRESPPP ...[more]