Ontology highlight
ABSTRACT:
SUBMITTER: Klein-Flugge MC
PROVIDER: S-EPMC3219831 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Klein-Flügge Miriam C MC Hunt Laurence T LT Bach Dominik R DR Dolan Raymond J RJ Behrens Timothy E J TE
Neuron 20111101 4
Reward prediction error (RPE) signals are central to current models of reward-learning. Temporal difference (TD) learning models posit that these signals should be modulated by predictions, not only of magnitude but also timing of reward. Here we show that BOLD activity in the VTA conforms to such TD predictions: responses to unexpected rewards are modulated by a temporal hazard function and activity between a predictive stimulus and reward is depressed in proportion to predicted reward. By cont ...[more]