Human nasal olfactory epithelium as a dynamic marker for CNS therapy development.
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ABSTRACT:
SUBMITTER: Sattler R
PROVIDER: S-EPMC3220936 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Publications
Human nasal olfactory epithelium as a dynamic marker for CNS therapy development.
Sattler Rita R Ayukawa Yoko Y Coddington Luke L Sawa Akira A Block David D Chipkin Richard R Rothstein Jeffrey D JD
Experimental neurology 20110916 2
Discovery of new central nervous system (CNS) acting therapeutics has been slowed down by the lack of useful applicable biomarkers of disease or drug action often due to inaccessibility of relevant human CNS tissue and cell types. In recent years, non-neuronal cells, such as astrocytes, have been reported to play a highly significant role in neurodegenerative diseases, CNS trauma, as well as psychiatric disease and have become a target for small molecule and biologic therapies. We report the dev ...[more]
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