Ontology highlight
ABSTRACT:
SUBMITTER: Thayil SM
PROVIDER: S-EPMC3221697 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
PloS one 20111121 11
Inorganic polyphosphate (poly P) has been postulated to play a regulatory role in the transition to bacterial persistence. In bacteria, poly P balance in the cell is maintained by the hydrolysis activity of the exopolyphosphatase PPX. However, the Mycobacterium tuberculosis PPX has not been characterized previously. Here we show that recombinant MT0516 hydrolyzes poly P, and an MT0516-deficient M. tuberculosis mutant exhibits elevated intracellular levels of poly P and increased expression of th ...[more]