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DNA nanotechnology for nucleic acid analysis: DX motif-based sensor.


ABSTRACT: A light on the tiles: A sensor that fluoresces in the presence of specific nucleic acids was designed and characterized. The sensor uses a molecular beacon probe and three adaptor strands to form a five-stranded assembly, a DX-tile, with a specific analyte. This sensor is a highly selective and affordable tool for the real-time analysis of DNA and RNA.

SUBMITTER: Kolpashchikov DM 

PROVIDER: S-EPMC3221779 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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DNA nanotechnology for nucleic acid analysis: DX motif-based sensor.

Kolpashchikov Dmitry M DM   Gerasimova Yulia V YV   Khan Mohammad S MS  

Chembiochem : a European journal of chemical biology 20111018 17


A light on the tiles: A sensor that fluoresces in the presence of specific nucleic acids was designed and characterized. The sensor uses a molecular beacon probe and three adaptor strands to form a five-stranded assembly, a DX-tile, with a specific analyte. This sensor is a highly selective and affordable tool for the real-time analysis of DNA and RNA. ...[more]

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