Ontology highlight
ABSTRACT:
SUBMITTER: Bui MN
PROVIDER: S-EPMC6637421 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Bui My N MN Brittany Johnson M M Viard Mathias M Satterwhite Emily E Martins Angelica N AN Li Zhihai Z Marriott Ian I Afonin Kirill A KA Khisamutdinov Emil F EF
Nanomedicine : nanotechnology, biology, and medicine 20170104 3
RNA nanotechnology employs synthetically modified ribonucleic acid (RNA) to engineer highly stable nanostructures in one, two, and three dimensions for medical applications. Despite the tremendous advantages in RNA nanotechnology, unmodified RNA itself is fragile and prone to enzymatic degradation. In contrast to use traditionally modified RNA strands e.g. 2'-fluorine, 2'-amine, 2'-methyl, we studied the effect of RNA/DNA hybrid approach utilizing a computer-assisted RNA tetra-uracil (tetra-U) m ...[more]