Ontology highlight
ABSTRACT:
SUBMITTER: Zaynagetdinov R
PROVIDER: S-EPMC3221921 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Zaynagetdinov Rinat R Sherrill Taylor P TP Polosukhin Vasiliy V VV Han Wei W Ausborn Jamie A JA McLoed Allyson G AG McMahon Frank B FB Gleaves Linda A LA Degryse Amber L AL Stathopoulos Georgios T GT Yull Fiona E FE Blackwell Timothy S TS
Journal of immunology (Baltimore, Md. : 1950) 20111102 11
Macrophages have established roles in tumor growth and metastasis, but information about their role in lung tumor promotion is limited. To assess the role of macrophages in lung tumorigenesis, we developed a method of minimally invasive, long-term macrophage depletion by repetitive intratracheal instillation of liposomal clodronate. Compared with controls treated with repetitive doses of PBS-containing liposomes, long-term macrophage depletion resulted in a marked reduction in tumor number and s ...[more]