Capturing the primordial Kras mutation initiating urethane carcinogenesis.
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ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC7156420 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Capturing the primordial Kras mutation initiating urethane carcinogenesis.
Li Siqi S MacAlpine David M DM Counter Christopher M CM
Nature communications 20200414 1
The environmental carcinogen urethane exhibits a profound specificity for pulmonary tumors driven by an oncogenic Q<sub>61</sub>L/R mutation in the gene Kras. Similarly, the frequency, isoform, position, and substitution of oncogenic RAS mutations are often unique to human cancers. To elucidate the principles underlying this RAS mutation tropism of urethane, we adapted an error-corrected, high-throughput sequencing approach to detect mutations in murine Ras genes at great sensitivity. This analy ...[more]
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