Ontology highlight
ABSTRACT:
SUBMITTER: Tanenbaum ME
PROVIDER: S-EPMC3223347 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Tanenbaum Marvin E ME Medema René H RH
Chromosoma 20110724 6
Efficient spindle assembly involves the generation of spatial cues around chromosomes that locally stabilize microtubule (MT) plus-ends. In addition to the small GTPase Ran, there is evidence that Aurora B kinase might also generate a spatial cue around chromosomes but direct proof for this is still lacking. Here, we find that the Aurora B substrate MCAK localizes to MT plus-ends throughout the mitotic spindle, but its accumulation is strongly reduced on MT plus-ends near chromatin, suggesting t ...[more]