Ontology highlight
ABSTRACT:
SUBMITTER: Khor CC
PROVIDER: S-EPMC3223402 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Khor Chiea Chuen CC Chau Tran Nguyen Bich TN Pang Junxiong J Davila Sonia S Long Hoang Truong HT Ong Rick T H RT Dunstan Sarah J SJ Wills Bridget B Farrar Jeremy J Van Tram Ta T Gan Tran Thi TT Binh Nguyen Thi Nguyet NT Tri Le Trung le T Lien Le Bich le B Tuan Nguyen Minh NM Tham Nguyen Thi Hong NT Lanh Mai Ngoc MN Nguyet Nguyen Minh NM Hieu Nguyen Trong NT Van N Vinh Chau Nguyen N Thuy Tran Thi TT Tan Dennis E K DE Sakuntabhai Anavaj A Teo Yik-Ying YY Hibberd Martin L ML Simmons Cameron P CP
Nature genetics 20111016 11
Hypovolemic shock (dengue shock syndrome (DSS)) is the most common life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from Vietnam. Replication of the most significantly associated markers was carried out in an independent Vietnamese sample of 1,737 cases and 2,934 controls. SNPs at two loci showed genome-wide significant association with DSS. We identified a susceptibility locus at MICB (major histoco ...[more]