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Genome-wide association study identifies two susceptibility loci for osteosarcoma.

ABSTRACT: Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. To better understand the genetic etiology of osteosarcoma, we performed a multistage genome-wide association study consisting of 941 individuals with osteosarcoma (cases) and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: a locus in the GRM4 gene at 6p21.3 (encoding glutamate receptor metabotropic 4; rs1906953; P = 8.1 × 10??) and a locus in the gene desert at 2p25.2 (rs7591996 and rs10208273; P = 1.0 × 10?? and 2.9 × 10??, respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma.

SUBMITTER: Savage SA 

PROVIDER: S-EPMC3910497 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Genome-wide association study identifies two susceptibility loci for osteosarcoma.

Savage Sharon A SA   Mirabello Lisa L   Wang Zhaoming Z   Gastier-Foster Julie M JM   Gorlick Richard R   Khanna Chand C   Flanagan Adrienne M AM   Tirabosco Roberto R   Andrulis Irene L IL   Wunder Jay S JS   Gokgoz Nalan N   Patiño-Garcia Ana A   Sierrasesúmaga Luis L   Lecanda Fernando F   Kurucu Nilgün N   Ilhan Inci Ergurhan IE   Sari Neriman N   Serra Massimo M   Hattinger Claudia C   Picci Piero P   Spector Logan G LG   Barkauskas Donald A DA   Marina Neyssa N   de Toledo Silvia Regina Caminada SR   Petrilli Antonio S AS   Amary Maria Fernanda MF   Halai Dina D   Thomas David M DM   Douglass Chester C   Meltzer Paul S PS   Jacobs Kevin K   Chung Charles C CC   Berndt Sonja I SI   Purdue Mark P MP   Caporaso Neil E NE   Tucker Margaret M   Rothman Nathaniel N   Landi Maria Teresa MT   Silverman Debra T DT   Kraft Peter P   Hunter David J DJ   Malats Nuria N   Kogevinas Manolis M   Wacholder Sholom S   Troisi Rebecca R   Helman Lee L   Fraumeni Joseph F JF   Yeager Meredith M   Hoover Robert N RN   Chanock Stephen J SJ  

Nature genetics 20130602 7

Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. To better understand the genetic etiology of osteosarcoma, we performed a multistage genome-wide association study consisting of 941 individuals with osteosarcoma (cases) and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: a locus in the GRM4 gene at 6p21.3 (encoding glutamate receptor metabotropic 4; rs1906953; P = 8.1 × 10⁻⁹) and a locus in the gene desert  ...[more]

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