Ontology highlight
ABSTRACT:
SUBMITTER: Murakami M
PROVIDER: S-EPMC3223828 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Murakami Masahiro M Nguyen Loc T LT Hatanaka Kunihiko K Schachterle William W Chen Pei-Yu PY Zhuang Zhen W ZW Black Brian L BL Simons Michael M
The Journal of clinical investigation 20110701 7
Numerous studies have suggested a link between the angiogenic FGF and VEGF signaling pathways; however, the nature of this link has not been established. To evaluate this relationship, we investigated VEGF signaling in ECs with disrupted FGF signaling in vitro and in vivo. ECs lacking FGF signaling became unresponsive to VEGF, caused by downregulation of VEGF receptor 2 (VEGFR2) expression after reduced Vegfr2 enhancer activation. FGF mediated VEGFR2 expression via activation of Erk1/2. Transcri ...[more]