Ontology highlight
ABSTRACT:
SUBMITTER: Hartwell RD
PROVIDER: S-EPMC6504108 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Hartwell Ryan D RD England Samantha J SJ Monk Nicholas A M NAM van Hateren Nicholas J NJ Baxendale Sarah S Marzo Mar M Lewis Katharine E KE Whitfield Tanya T TT
PLoS genetics 20190425 4
In the zebrafish, Fgf and Hh signalling assign anterior and posterior identity, respectively, to the poles of the developing ear. Mis-expression of fgf3 or inhibition of Hh signalling results in double-anterior ears, including ectopic expression of hmx3a. To understand how this double-anterior pattern is established, we characterised transcriptional responses in Fgf gain-of-signalling or Hh loss-of-signalling backgrounds. Mis-expression of fgf3 resulted in rapid expansion of anterior otic marker ...[more]