NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.
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ABSTRACT:
SUBMITTER: Yamamoto H
PROVIDER: S-EPMC3225739 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.
Yamamoto Hiroyasu H Williams Evan G EG Mouchiroud Laurent L Cantó Carles C Fan Weiwei W Downes Michael M Héligon Christophe C Barish Grant D GD Desvergne Béatrice B Evans Ronald M RM Schoonjans Kristina K Auwerx Johan J
Cell 20111101 4
Transcriptional coregulators control the activity of many transcription factors and are thought to have wide-ranging effects on gene expression patterns. We show here that muscle-specific loss of nuclear receptor corepressor 1 (NCoR1) in mice leads to enhanced exercise endurance due to an increase of both muscle mass and of mitochondrial number and activity. The activation of selected transcription factors that control muscle function, such as MEF2, PPARβ/δ, and ERRs, underpins these phenotypic ...[more]
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