Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi SS
PROVIDER: S-EPMC6932742 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Life science alliance 20191226 1
Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, such as after a meal. LDs serve as an energy reservoir during fasting and have a buffering capacity that prevents lipotoxicity. Autophagy and the autophagic machinery have been proposed to play a role in LD biogenesis, but the underlying molecular mechanism remains unclear. Here, we show that when nuclear receptor co-repressor 1 (NCoR1), which inhibits the transactivation of nuclear receptors, ac ...[more]