Ontology highlight
ABSTRACT:
SUBMITTER: Jones CK
PROVIDER: S-EPMC3226828 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Jones Carrie K CK Engers Darren W DW Thompson Analisa D AD Field Julie R JR Blobaum Anna L AL Lindsley Stacey R SR Zhou Ya Y Gogliotti Rocco D RD Jadhav Satyawan S Zamorano Rocio R Bogenpohl Jim J Smith Yoland Y Morrison Ryan R Daniels J Scott JS Weaver C David CD Conn P Jeffrey PJ Lindsley Craig W CW Niswender Colleen M CM Hopkins Corey R CR
Journal of medicinal chemistry 20111019 21
There is an increasing amount of literature data showing the positive effects on preclinical antiparkinsonian rodent models with selective positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)). However, most of the data generated utilize compounds that have not been optimized for druglike properties, and as a consequence, they exhibit poor pharmacokinetic properties and thus do not cross the blood-brain barrier. Herein, we report on a series of N-4-(2,5-dioxopyrrolidin-1- ...[more]