Evidence for Elevated Cerebrospinal Fluid ERK1/2 Levels in Alzheimer Dementia.
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ABSTRACT:
SUBMITTER: Spitzer P
PROVIDER: S-EPMC3227514 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Evidence for Elevated Cerebrospinal Fluid ERK1/2 Levels in Alzheimer Dementia.
Spitzer Philipp P Schieb Heinke H Kamrowski-Kruck Heike H Otto Markus M Chiasserini Davide D Parnetti Lucilla L Herukka Sanna-Kaisa SK Schuchhardt Johannes J Wiltfang Jens J Klafki Hans-Wolfgang HW
International journal of Alzheimer's disease 20111124
Cerebrospinal fluid (CSF) samples from 33 patients with Alzheimer dementia (AD), 21 patients with mild cognitive impairment who converted to AD during followup (MCI-AD), 25 patients with stable mild cognitive impairment (MCI-stable), and 16 nondemented subjects (ND) were analyzed with a chemiluminescence immunoassay to assess the levels of the mitogen-activated protein kinase ERK1/2 (extracellular signal-regulated kinase 1/2). The results were evaluated in relation to total Tau (tTau), phosphory ...[more]
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