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Stereospecific total synthesis of somocystinamide A.

ABSTRACT: The first total synthesis of somocystinamide A, a disulfide dimer with extremely labile enamide functional groups, was accomplished in a concise and stereospecific manner. Somocystinamide A is reported to possess exceptionally potent antiangiogenic and tumoricidal activities. The current work should enable further pharmacological investigation of this important natural product.

SUBMITTER: Suyama TL

PROVIDER: S-EPMC3227555 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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Stereospecific total synthesis of somocystinamide A.

Suyama Takashi L TL Gerwick William H WH

Organic letters 20080913 20

The first total synthesis of somocystinamide A, a disulfide dimer with extremely labile enamide functional groups, was accomplished in a concise and stereospecific manner. Somocystinamide A is reported to possess exceptionally potent antiangiogenic and tumoricidal activities. The current work should enable further pharmacological investigation of this important natural product. ...[more]

PMID: 18788741

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