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Stereospecific synthesis of phosphatidylglycerol using a cyanoethyl phosphoramidite precursor.

ABSTRACT: Phosphatidylglycerols (PG) are a family of naturally occurring phospholipids that are responsible for critical operations within cells. PG are characterized by an (R) configuration in the diacyl glycerol backbone and an (S) configuration in the phosphoglycerol head group. Herein, we report a synthetic route to provide control over the PG stereocenters as well as control of the acyl chain identity.

SUBMITTER: Struzik ZJ

PROVIDER: S-EPMC7484214 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Stereospecific synthesis of phosphatidylglycerol using a cyanoethyl phosphoramidite precursor.

Struzik Zachary J ZJ Weerts Ashley N AN Storch Judith J Thompson David H DH

Chemistry and physics of lipids 20200611

Phosphatidylglycerols (PG) are a family of naturally occurring phospholipids that are responsible for critical operations within cells. PG are characterized by an (R) configuration in the diacyl glycerol backbone and an (S) configuration in the phosphoglycerol head group. Herein, we report a synthetic route to provide control over the PG stereocenters as well as control of the acyl chain identity. ...[more]

PMID: 32533981

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