Ontology highlight
ABSTRACT:
SUBMITTER: Malloy KL
PROVIDER: S-EPMC3227558 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Malloy Karla L KL Villa Francisco A FA Engene Niclas N Matainaho Teatulohi T Gerwick Lena L Gerwick William H WH
Journal of natural products 20101214 1
A Papua New Guinea collection of the marine cyanobacterium cf. Lyngbya sordida yielded three known compounds as well as a new PKS-NRPS-derived malyngamide with anti-inflammatory and cytotoxic activity. Malyngamide 2 features an extensively oxidized cyclohexanone ring. Resolution of the ring core as a 6,8,9-triol rather then a 7,8,9-triol and relative configuration was based on chemical shift and bond geometry modeling in conjunction with homonuclear and heteronuclear coupling constants, NOE and ...[more]