Specific knockdown of the D2 long dopamine receptor variant.
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ABSTRACT:
SUBMITTER: Naughton BJ
PROVIDER: S-EPMC3227782 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Specific knockdown of the D2 long dopamine receptor variant.
Naughton Bart J BJ Thirtamara-Rajamani Keerthi K Wang Chuansong C During Matthew J MJ Gu Howard H HH
Neuroreport 20120101 1
Dopamine signaling in the nucleus accumbens is critical in mediating the effects of cocaine. There are two splice variants of dopamine D2 receptors, D2L and D2S, which are believed to have different functional roles. Here, we show, that knocking down D2L selectively using viral-mediated short-hairpin RNA led to a slight but significant decrease in basal locomotor activity with no significant change in cocaine-induced stimulation of locomotion. The knockdown appears to produce a trend of reduced ...[more]
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